జర్నల్ ఆఫ్ అల్జీమర్స్ డిసీజ్ & పార్కిన్సోనిజం

నైరూప్య

Soluble Neuregulin-1 as a Diagnostic Biomarker for Alzheimer's Disease

Hyunjeong Liew and Sang Hyung Lee

Diagnosis using a biomarker is a faster and cheaper than brain imaging. Diagnostic biomarkers are chosen based on the characteristics of the disease, specificity, sensitivity, and stability during all disease stages. For this reason, previous candidates with insoluble form in a pathophysiological stage are not useful as biomarkers for the early stage of a neurodegenerative disease. In this study, we explored the possibility of using soluble proteins in cerebrospinal fluid, blood, or other peripheral materials as diagnostic biomarkers, in particular, the availability of soluble neuregulin-1 in blood.