జర్నల్ ఆఫ్ అల్జీమర్స్ డిసీజ్ & పార్కిన్సోనిజం

నైరూప్య

Parkinson's Disease (Pathogenesis and Its Management): An Overview

Kumar BNP, Naresh Korrapati, Shabana Kouser Ali and Shaik Mohammed Irshad

Parkinson’s disease (PD) is an idiopathic neurodegenerative disorder which has its incidence mainly in elderly aged humans. Loss of dopaminergic neurons especially in the substantia nigra, presence of α-synuclein Lewy bodies, mitochondrial dysfunction are the main pathological implications that plays pivotal role in both sporadic and familial forms of the disease. As PD affects older adults mostly in economically developed countries and worldwide aging populations there is an urgent need to develop strategies for the health care of individuals with PD. Epidemiological studies help in better understanding of the risk factors for PD and also helps in management of the disease and effective planning of medical services. In this present review article current understanding of Pathophysiology, Risk factors of PD were presented and the latest therapeutic approaches were discussed.