న్యూట్రిషన్ సైన్స్ రీసెర్చ్ జర్నల్

నైరూప్య

Association between Ventilatory Thresholds Related to Aerobic Fitness and MCT1 A1470T Polymorphism

Leonardo A Pasqua, Mayara V Damasceno, Salomão Bueno, Gustavo G de Araújo Adriano E Lima-Silva and Rômulo Bertuzzi

The purpose of this study was to verify the association between MCT1 polymorphism with physiological parameters related to aerobic fitness. A hundred fifty healthy male volunteers performed a maximal incremental running test to determine the speeds corresponding to Ventilatory Threshold (VT) and Respiratory Compensation Point (RCP). Participants were genotyped and divided in terciles based on the analyzed variables. Genotype frequencies were compared through chi-square test between lower (LT) and higher terciles (HT), with the lowest or highest values of each analyzed variable. MCT1 TT genotype was overrepresented in HT only for VT and showed a significantly higher odds ratio of belong to HT for VT compared only to AA (5.1). These results suggest that TT individuals could attain the VT and RCP at higher speeds, being able to sustain higher running speeds in lower exercise intensity domains. In other words, it is possible that individuals carrying the MCT1 TT genotype might run at higher speeds with lower fatigue signals, mimicking an inner aerobic fitness adaptation.