ఇంటర్నేషనల్ జర్నల్ ఆఫ్ రీసెర్చ్ అండ్ డెవలప్‌మెంట్ ఇన్ ఫార్మసీ & లైఫ్ సైన్సెస్

నైరూప్య

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL N10-ALKYL SUBSTITUTED ACRIDINE- 9-ONE DERIVATIVES

S.K.Gupta, Pankaj Baboo

N-Phenyl anthranilic acid was prepared by Ullmann condensation of o-chlorobenzoic acid and aniline. The N-phenyl anthranilic acid was cyclized with polyphosphoric acid over a water bath at 100°C to form acridin-9(10H)-one. N10-Alkylated acridin-9-ones were synthesized in two series, in first series, N10- alkylation with 1-bromo-3-chloro propane and in second series with 1,2-dichloroethane were done by using tetrabutyl ammonium bromide as phase transfer catalyst. Later both were derivatized by refluxing with different secondary amines in presence of potassium carbonate using anhydrous acetonitrile as solvent. The newly synthesized compounds were purified by column chromatography. The formation of title compounds confirmed by physical and spectral data. The synthesized compounds were subjected to microbiological screening.