జర్నల్ ఆఫ్ క్లినికల్ & ఎక్స్‌పెరిమెంటల్ న్యూరోఇమ్యునాలజీ

నైరూప్య

Large-Scale Brain Networks Alterations in Migraine

Kirill Markin, Artem Trufanov, Daria Frunza, Dmitriy Tarumov

Background: An increasing number of researches on large-scale brain network alterations among migraine patients has prompted us to make a brief review of them.

Methods: We performed a literature search for original articles reporting data from resting-state functional connectivity secondary analyses for migraine patients only or compared with healthy controls. This review includes only large-scale brain network studies among migraine patients within the last five years.

Results: We founded 16 studies, including two during the ictal period and 14 during the migraine interictal period. The most significant alterations among migraine patients were founded across Default Mode Network, Salience Network, Sensori Motor Network, Executive Control Network, Visual Network, and Dorsal Attention Network.

Conclusion: Large-scale brain networks FC studies could help reveal hidden pathophysiological mechanisms of the migraine. Methodological guidelines will significantly improve the reproduction and possibility of comparing the FC studies, enhancing their scientific and clinical contributions.