జర్నల్ ఆఫ్ మాలిక్యులర్ ఫార్మాస్యూటిక్స్ & ఆర్గానిక్ ప్రాసెస్ రీసెర్చ్

నైరూప్య

In-vitro refolding of recombinant human (rh) Prolidase using smart polymer

Sayantap Datta

Statement of the Problem: A member of the metallopeptidase family, Prolidase is an exopeptidase involved in the final steps of the catabolism of proline-rich and hydroxyproline-rich dietary and endogenous proteins such as collagen. Mutations in the gene encoding for prolidase brings about autosomal recessive prolidase deficiency characterized by intractable ulcerations in the skin, varied extent of mental retardation and recurrent infections of the respiratory tract. Prolidase has additionally been known to function similar to organophosphorus acid anhydrolase in hydrolyzing organophosphorus compounds