ఇంటర్నేషనల్ జర్నల్ ఆఫ్ ఎమర్జెన్సీ మెంటల్ హెల్త్ అండ్ హ్యూమన్ రెసిలెన్స్

నైరూప్య

Identification and Prevention of Serotonin Syndrome

Mohammad Masud Iqbal, Saabry Yusof Osmany and Mohamamd Tamzid Iqbal

Serotonin Syndrome (SS) is a rare, but lethal, adverse drug reaction caused by excessive serotonin activity in the nervous system. Serotonin syndrome is more accurately described as serotonin toxicity and can be triggered by serotonergic agents either alone or in combination with monoamine oxidase inhibitors (MAOIs). It may occur after one standard therapeutic dose of a single agent, unintentional interactions between various medications, drug overdose, as well as recreational drug use. Symptoms present as alteration of mental status, abnormalities of neuromuscular tone, and autonomic hyperactivity. Although effects are usually mild and resolve with prompt recognition and supportive care, there exists a strong need for integration of these preventative measures in current clinical practice.