జర్నల్ ఆఫ్ న్యూట్రిషన్ అండ్ డైటెటిక్స్

నైరూప్య

Failure in losing weight process duet to three factors: altered microbiota, psychiatric disorders and impaired feeding behavior

Marjan Moallemian Isfahani

With regards to modern lifestyle changes, people’s lives have been changed more into sedentary behaviors. Indeed, the prevalence of obesity is
increasing among people every day and it becomes one of the most important cause of diseases and morbidity in the world. Meanwhile, many studies
have shown that most of the obese individuals have illustrated to suffer from anxiety or depression or both as psychiatric diseases. In addition, the desire
to intake the foods containing high fat and carbohydrate components and overeating is more common in obesity. The Gut is known as an independent
organ due to its role in monitoring or controlling the eating behavior through the gut brain axis (GBA) and also gut microbiota have displayed a crucial
role in this case. Changes in microbiota can impact on impaired brain function and feeding behavior as well. Consequently, Obesity and weight
fluctuations are complex issues which are influenced by many reasons. Thereby, based on our studies we came into conclusion that there is a visous
cycle between the intestinal microbiota and its changes as a result of anxiety and depression as well as the incidence of emotional and uncontrolled
eating due to altered gut microbiota and in order to optimize the efficacy and weaken the failure in losing weight process, it needs to have a holistic
approach to diet and weight loss and general advice can not be effective as much as an individualized diet plan along with taking into account the
psychological disorders.