జర్నల్ ఆఫ్ క్లినికల్ & ఎక్స్‌పెరిమెంటల్ పాథాలజీ

నైరూప్య

Cytological and Histopathology Features of Meibomian Adenocarcinoma in a Dog Terrier Breed

Abbas Tavasoli, Javad Javanbakht, Radmehr Shafiee, Zahra Kamyabi-moghaddam and Mehdi Aghamohammad Hassan

Abstract
In March 2012, an 8-year-old neutered terrier which was admitted to the Veterinary Surgery Clinics of Faculty of
Veterinary Medicine, University of Tehran, Iran. The signalment (i.e. description of appearance of the animals such as
sex, breed, age, etc) and anatomical repartition were summarized and focused on pathomorphological explanation.
Macroscopically, the mass was gray-reddish and arising from the right lower eyelid with local spread to the upper
eyelid and covering the entire globe was observed. Following sedation and local anesthesia, the tumor and globe were
expulsed with Cryosurgery. Cytological smears indicated large number of malignant meibomian cells occurring
either individually or in clusters also cytology indicated high cellularity and contained small clusters of polygonal to
elongated tumor cells. Microscopically, the mass was composed of lobules of various sizes separated with a septum of
connective tissue which included with poorly differentiated (grade III), nuclear pleomorphism and polygonal sebaceous
cells, also with acinular and sheet-like architecture, the findings are consistent with minimal mitotic activity, extensive
invasion, low grade and the presence of hyaline cartilage. Finally, histopathological examination revealed an MAC.