సైటోకిన్ బయాలజీ జర్నల్

నైరూప్య

Cytokines and Infertility Influence of Cytokines and Local Inflammation in Women of Reproductive Age with Infertility

Alexander Trunov, Olga Obukhovа, Olga Gorbenko, Alevtina Shvayk and Liliya Trunovа

Objective: The objective of the study was to investigate concentrations of cytokines in peritoneal fluid from women with infertility and chronic infectious inflammation (CII) of reproductive system. Methods: 65 patients were included to the study: 50 patients were diagnosed with tubo-peritoneal infertility and CII of reproductive system in remission (CII was of bacterial origin); 15 patients were almost healthy age-matched woman. The concentrations of TNF-α, IL-4, IL-6, IL-10, monocyte chemo attractant protein-1 (MCP-1), IFN-γ and sVCAM-1 were measured in peritoneal fluid using enzyme-linked immunoassay. Results: Peritoneal fluid levels of TNF-α, IL-4, IL-6, IFN-γ, MCP-1, sVCAM-1 were significantly (p<0.05) higher in patients with infertility and CII compared to control group. The most significant difference (4.52 times) was found for IFN-γ concentrations. The concentration of IL-10 was not significantly differing between the groups. Conclusions: Local inflammation and activation of immune reactions with cytokines imbalance in patients with CII of reproductive system may play a role in the pathogenesis of tubo-peritoneal infertility.