జర్నల్ ఆఫ్ మ్యూకోసల్ ఇమ్యునాలజీ రీసెర్చ్

నైరూప్య

Chronic illness and the development of the immune system

Bei Liu

A variety of cell types are involved in the complicated, coordinated, spatiotemporal process of tissue healing and regeneration, and their activity must be strictly controlled in order for successful tissue repair to occur after damage.In particular, given an ageing population in which obesity, diabetes, and the resulting tissue defects have reached epidemic proportions, new therapeutic strategies are needed to treat a number of globally prevalent conditions such as heart disease, organ failure, and severe musculoskeletal disorders. This is further worse by the fact that some adult tissues have limited regeneration abilities and little inherent ability for repair. The practical use of tissue regeneration techniques to promote self-healing, such as by the implantation of tissue-engineered scaffolds, has faced several obstacles in the past decade despite the significant progress that has been achieved in this area application of these technologies.

Controlling the immune response is becoming a more appealing strategy in regenerative medicine, and it is clear that a thorough understanding of the interactions between immune system cells and tissue-specific progenitor cells is crucial. The effectiveness of biomaterial-based tissue repair and regeneration is also expected to increase with the merging of immunology and bioengineering. In this review, we focus on the specific roles that various immune cell subsets play in tissue repair processes and discuss innovative strategies being used to target immune cell activity using biomaterials in order to achieve the desired healing results.