మా గ్రూప్ ప్రతి సంవత్సరం USA, యూరప్ & ఆసియా అంతటా 3000+ గ్లోబల్ కాన్ఫరెన్స్ ఈవెంట్లను నిర్వహిస్తుంది మరియు 1000 కంటే ఎక్కువ సైంటిఫిక్ సొసైటీల మద్దతుతో 700+ ఓపెన్ యాక్సెస్ జర్నల్లను ప్రచురిస్తుంది , ఇందులో 50000 మంది ప్రముఖ వ్యక్తులు, ప్రఖ్యాత శాస్త్రవేత్తలు ఎడిటోరియల్ బోర్డ్ సభ్యులుగా ఉన్నారు.
ఎక్కువ మంది పాఠకులు మరియు అనులేఖనాలను పొందే ఓపెన్ యాక్సెస్ జర్నల్స్
700 జర్నల్స్ మరియు 15,000,000 రీడర్లు ప్రతి జర్నల్ 25,000+ రీడర్లను పొందుతున్నారు
Kazuma Kobayashi, Fumihiko Fujita, Yusuke Inoue, Chika Sakimura, Sayaka Kuba, Taiiichiro Kosaka, Taiiichiro Kosaka, Kosho Yamanouchi, Kengo Kanetaka, Tamotsu Kuroki and Susumu Eguchi
Purpose: In Japan, elderly people account for more than 20% of the total population. The incidence of elderly patients with advanced/recurrent colorectal cancer (ARCC) has also been increasing. However, the optimal regimen for elderly patients, especially those older than 75 years of age (late-stage elderly), has not been established. This study aims to examine the optimal chemotherapeutic regimens for late-stage elderly patients, and focuses on combined chemotherapy with Bevacizumab (Bmab)+dihydropyrimidine (DPD) dehydrogenase inhibitory fluoropyrimidine (DIF).
Methods: Between January 1996 and October 2014, 30 late-stage elderly chemotherapy-naïve patients with ARCC (male/female=16/14; average age, 79.1 years) were retrospectively reviewed. The treatment regimens were: Bmab+DIF (n=11) and other regimens (n=19).
Results: The MST was 979 days, the median PFS was 350 days and the RR was 23.3%. The grade ≥3 AEs with each of the regimens were as follows: Bmab+DIF, 1.9%, other regimens, 14.4%. Although no significant differences were observed in the OS or PFS between Bmab+DIF and the other regimens, the rate of transition to a 2nd-line chemotherapy after disease progression following first-line treatment was higher with Bmab+DIF (54.6% [6/11]) than with the other regimens (38.9% [7/18]); however, this difference did not reach statistical significance.
Conclusions: It is possible to prolong survival through chemotherapy in both late-stage elderly patients and younger patients with ARCC. Although the only appropriate specific regimen was not confirmed, given that it was associated with a 100% disease control rate, good feasibility and smooth transition to 2nd-line chemotherapy, Bmab+DIF was suggested to be a candidate treatment for late-stage elderly patients with ARCC.