ఇన్నోవేటివ్ ఎనర్జీ & రీసెర్చ్

నైరూప్య

Alcohol Dehydrogenases Catalyzing the Production of Ethanol at High Temperatures

Navin Asokumar, Sarah Danielle Kim and Kesen Ma

Alcohol dehydrogenases (ADHs) are a group of enzymes within the class of oxidoreductases that catalyze the interconversion of alcohols to their corresponding aldehydes and ketones, and can be categorized into three different types (type I, II, and III) depending on the molecular size and metal requirements. Hyperthermophilic ADHs have superior catalytic properties compared to their mesophilic counterparts, due to their high tolerance of extreme conditions such as high temperatures. There are 19 hyperthermophilic ADHs that have been characterized. This review focuses on understanding biochemical and biophysical properties of hyperthermophilic ADHs involved in ethanol production at high temperatures.